Bone implant interface, osteolysis and potential therapies.
نویسندگان
چکیده
منابع مشابه
Aseptic loosening of total joint replacements: mechanisms underlying osteolysis and potential therapies
Total joint replacement, although considered an excellent surgical procedure, can be complicated by osteolysis induced by implant particles and subsequent aseptic loosening of the implant. The pathogenesis of implant-associated osteolysis includes inflammatory and osteolytic processes. The sustained chronic inflammatory response initiated by particulate debris at the implant-bone interface is m...
متن کاملBone-Implant Interface Biology ―― Foreign Body Reaction and Periprosthetic Osteolysis in Artificial Hip Joints――
Aseptic loosening and periprosthetic osteolysis are major problems in artificial hip joint surgery,for which a solution has yet to be found. Biological host response to wear debris combined with cyclic mechanical loading onto the bone bed around hip prosthetic implants has been considered as mechanism responsible for implant-mediated periprosthetic osteolysis. Any type of artificial joint glidi...
متن کاملAseptic loosening and osteolysis: etiology, pathogenesis, and cellular responses
Total joint replacement, although considered an excellent surgical procedure, can be complicated by osteolysis induced by implant particles and subsequent aseptic loosening of the implant. The pathogenesis of implant-associated osteolysis includes inflammatory and osteolytic processes. The sustained chronic inflammatory response initiated by particulate debris at the implant-bone interface is m...
متن کاملPrevention of Wear Particle-Induced Osteolysis by a Novel V-ATPase Inhibitor Saliphenylhalamide through Inhibition of Osteoclast Bone Resorption
Wear particle-induced peri-implant loosening (Aseptic prosthetic loosening) is one of the most common causes of total joint arthroplasty. It is well established that extensive bone destruction (osteolysis) by osteoclasts is responsible for wear particle-induced peri-implant loosening. Thus, inhibition of osteoclastic bone resorption should prevent wear particle induced osteolysis and may serve ...
متن کاملCurrent research in the pathogenesis of aseptic implant loosening associated with particulate wear debris.
Periprosthetic osteolysis is the most common long-term complication of a total joint arthroplasty, often resulting in aseptic loosening of the implant, which occurs in up to 34% of younger implant recipients and usually requires surgical revision. Particulate wear debris, continuously generated by articulating motion at the bearing surfaces, has been implicated as one of the primary causes of p...
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عنوان ژورنال:
- Journal of musculoskeletal & neuronal interactions
دوره 4 4 شماره
صفحات -
تاریخ انتشار 2004